Fakultät für Mathematik und Naturwissenschaften

Target oriented Synthesis

Two fundamental strategies for the total synthesis of complex compounds are employed. In one, the pure number of synthetic steps will be minimized. This requires the development of novel domino reactions for the creation of key structural motifs in target compounds many of which are found in terpenoids and stereoids. In the second more challenging variant, we plan to develop and continuously extend a general strategy for the rapid synthesis of polyketide-derived compounds. Herein, the exclusive use of well-established reactions is believed to lead to a simplification of the synthetic scheme. The main focus relies on the general applicability of this strategy.

Strategy 1: Development of novel domino reactions for the use in the total synthesis of terpenoids and stereoids.

  • Minimizing the number of synthetic steps (e.g., low percentage of protecting group operations and redox reactions, high percentage of C-C-bond formations and cascade reactions)
  • Successful development leading to i) short synthesis route, ii) selective access to one target compound, iii) economical and ecological benefits

Strategy 2: Development of a general strategy for the de-novo synthesis of polyketides.

  • Simplification of synthetic steps (e.g., exclusive use of well-established reactions, experimental ease, low percentage of "risky" domino reactions)
  • Short time-requirements for planning and development (low risk)
  • Successful development leading to i) long synthesis route, ii) flexible access to a class of target compounds, iii) general applicability

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